As we age in years, we experience a lot of changes in our body and in our daily activities. That’s why we take in supplements like Rocket Man NaturalsĀ to improve our blood circulation and keep us active. Our pet dogs go through the same aging process. And yes, they also need supplements to help them keep up with aging.
Our pets are part of the family that’s why the optimal use of existing treatment options is as important as seeking treatment options for our elder loved ones.
Much like humans, there are advances in diet and general health care intended for our pet dogs. To the same extent, dog owners place higher demands on health care and the quality of life of their four-legged friends.
Noticeable changes among aging dogs
In our society, pets are increasingly seen as “family members” who live in close relationship with their owners. As a result, aging processes in pets are more noticeable.
These processes include increasing inactivity, the loss of house-training, changed sleeping habits and increasing disorientation. Many of these changes develop insidiously or are initially considered “normal” ones.
Signs of aging among dogs are acceptable until they reach an advanced stage when they become increasingly hard to manage. For this reason, it is becoming increasingly important to make full use of the treatment options available to older dogs.
Decrease in Adrenosine among aging dogs
It is known from human medicine that the effect of adenosines can decrease with increasing age. Such a decrease in the effect of adenosine can also contribute to the clinical signs of aging in older dogs.
Drugs that potentiate the effects of adenosine can therefore slow the effects of aging in dogs. This can reduce the problems associated with age with regard to the health and relationship between the owner and the dog.
A strong stimulator of adenosine is the xanthine derivative propentofylline which has been shown to have a broad range of effects on the flow properties of blood, cardiovascular function, cerebral blood flow and the diameter of the airways. The numerous positive pharmacological effects of propentofylline result in an overall profile that makes this active ingredient particularly suitable for the treatment of frequently occurring dysfunctions in geriatric k9 patients.
Adenosine in the aging process and the potentiating effects of propentofylline
As in humans, a decline in the effects of adenosine in dogs can also contribute to the aging symptoms. Can this process be used to alleviate the effects of the aging process?
It is known from human medicine that adenosine receptor function and adenosine effect can decrease in old age . Such a decrease in the effect of adenosine can also contribute to the typical clinical signs of aging in older dogs. These symptoms include circulatory deterioration, poor neuromuscular transmission with muscle weakness and reduced exercise tolerance, and increased platelet aggregation with thrombus formation, as well as neurodegenerative changes.
A potentiation of the adenosine effects therefore appears suitable to alleviate or even stop the effects of the aging process on the health of older dogs. The use of adenosine-potentiating products leads, among other things, to an improvement in the peripheral and central blood flow in older dogs.
The xanthine derivative propentofylline is a powerful stimulator of adenosine and an inhibitor of cAMP phosphodiesterase. It has numerous vascular and non-vascular effects. Propentofylline inhibits the uptake of adenosine in the nerve endings and other cells and leads to an increased extracellular availability of adenosine. In this way, the various positive effects of adenosine can be increased.
By inhibiting cAMP phosphodiesterase, the breakdown of cAMP is inhibited. At the same time, the intracellular cAMP concentration is increased and the ATP level is stabilized. The positive effect of propentofylline on the deformability of the erythrocytes is based on this mechanismand the inhibition of platelet aggregation and bronchodilation. In addition, propentofylline leads to an increased formation of cAMP and cGMP via the stimulating effect of adenosine on the enzyme adenylate cyclase .
